No. 5 Fantastic Voyage (1966)
A miniature spacecraft and crew are injected into a comatose scientist to remove a life-threatening blood clot, so that he can survive to share vital secrets. The movie's lavishly depicted workings of the human body garnered two Academy Awards and three additional nominations—and got James Giordano thinking about medicine at the tiniest scale. Now a professor of neuroscience at Georgetown University, Giordano examines the mechanics of the brain's response to pain. "The film has been a lifelong inspiration for me to work on developing neurotechnology," he says. David Carroll, director of the Center for Nanotechnology and Molecular Materials at Wake Forest University, says that the movie's minuscule technology, although physically impossible, is echoed in his current work. "It's exactly what we are working on: Injecting nanobots that find a cancerous tumor, tell us when they have found it, and destroy it," he says. Now that's fantastic.