"The imperfect is our paradise," Wallace Stevens wrote. If the entry of genetics into the human world carried one immediate lesson, it was this: the imperfect was not just our paradise; it was also, inextricably, our mortal world. The degree of human genetic variation—and the depth of its influence on human pathology—was unexpected and surprising. The world was vast and various. Genetic diversity was our natural state—not just in isolated pockets in faraway places, but everywhere around us. Seemingly homogeneous populations were, in fact, strikingly heterogeneous. We had seen the mutants—and they were us.
-Siddhartha Mukherjee, The Gene: An Intimate History
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