"'It is not easy to express the inexpressible,' he answered with a laugh. 'Holmes is a little too scientific for my tastes - it approaches to cold-bloodedness. I could imagine his giving a friend a little pinch of the latest vegetable alkaloid, not out of malevolence, you understand, but simply out of a spirit of inquiry in order to have an accurate idea of the effects. To do him justice, I think that he would take it himself with the same readiness. He appears to have a passion for definite and exact knowledge.'"
-Arthur Conan Doyle, A Study in Scarlet
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