The original Great Game may have been the nickname for the geopolitical machinations of rival powers, Great Britain and Russia, during the nineteenth century. The current Great Game would seem to be the contest between the Regulators and the Regulated. Barring a massive and aggressive police state, the safe bet is on the Regulated (with a side bet on the ever-unpredictable Law of Unintended Consequences). The Economist is on the story:
"Time and again, the imposition of new burdens on business distorts the flow of money......Finance has yet to meet a rule it doesn't want to game."