Inspiration came to Sanger unexpectedly in the winter of 1971—in the form of inversion. He had spend decades learning to break molecules apart to solve their sequence. But what if he turned his own strategy upside down and tried to build DNA, rather than break it down? To solve a gene sequence, Sanger reasoned, one must think like a gene.
-Siddhartha Mukherjee, The Gene: An Intimate History